|
West Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined cerebrospinal fluid (CSF) concentrations for neurotrophins, nerve growth factor (β-NGF) and insulin-like growth factor (IGF-1) in children with infantile spasms between 1997 and 2010.
|
30503720 |
2019 |
|
Vulvodynia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Localized Provoked Vulvodynia: Association With Nerve Growth Factor and Transient Receptor Potential Vanilloid Type 1 Genes Polymorphisms.
|
30418350 |
2019 |
|
Vulvodynia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Nerve Growth Factor and Selected Cytokines in Women With and Without Vulvodynia.
|
29570566 |
2018 |
|
Visual seizure
|
0.300 |
Biomarker
|
disease |
CTD_human |
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.
|
18815271 |
2008 |
|
Vertiginous seizure
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.
|
18815271 |
2008 |
|
Ventricular arrhythmia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, micro-injection of the NF-κB inhibitor pyrrolidine dithiocarbamate into PVN in MI rats, significantly inhibited the activation of NF-κB and further reduced the expression of IL-1β and NGF in the PVN, finally blunting sympathetic hyperinnervation in the heart, moreover, the blockade of NF-κB in the PVN reduced the incidence of ventricular arrhythmias (VAs).
|
31175933 |
2019 |
|
Ventricular arrhythmia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, miR-155 inhibition downregulated NGF expression via decreasing M1 macrophage polarization and inflammatory responses dependent on the SOCS1/NF-κB pathway, subsequently diminishing MI-induced sympathetic neural remodeling and ventricular arrhythmias (VAs).
|
30721702 |
2019 |
|
Vasculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, serum nerve growth factor (NGF) was significantly elevated in LCWE-injected mice, similar to children with KD vasculitis, associated with increased neural remodeling of the myocardium.
|
31758701 |
2020 |
|
Varicosity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Predominantly, at the early stage of the infection, cardiac autonomic varicosities displayed several signs of degeneration parallel to the elevation of cardiac levels of NGF, as well as expression of the receptors TrkA and p75NTR.
|
29117739 |
2017 |
|
Uveal melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin 6, 8 (IL-6, IL-8, respectively), interferon-inducible protein-10 (IP-10), placental growth factor1 (PIGF1), regulated on activation, normal T Cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1), nerve growth factor-beta (NGF-β), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and vascular endothelia growth factor A (VEGF-A) were assessed by multiplex bead assay.In the study group, significantly higher concentrations of IL-6 (P = .006), IL-8 (P = .018), IP-10 (P = .004), RANTES (P = .008), MCP-1 (P = .02), NGF-β (P = .013), EGF (P < .001), PIGF1 (P = .01), bFGF (P = .016), and VEGF (P = .017) were measured, when compared with the control group.Several angiogenic, inflammatory, and chemotactic cytokines are highly expressed in the aqueous humor of the UM eyes, which provides new insights into the pathophysiology of UM and could be potential targets for treatment.
|
30702560 |
2019 |
|
Uterine Fibroids
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Are selective markers for the neuronal differentiation such as microtubule-associated protein 2 (MAP-2) and synaptophysin (SYP) as well as the nerve growth factor (NGF) expressed by fibroids, myometrium and eutopic endometrium?
|
31732726 |
2019 |
|
Urticaria
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Our study suggests that chronic spontaneous urticaria is linked with changes serum nerve growth factor levels, and that the deregulation of neurotrophins may contribute to urticaria pathophysiology.
|
19054925 |
2009 |
|
Urinary symptoms
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
NGF and BDNF levels were measured and compared in 38 children (28 boys and 10 girls) with MNE and 25 children (18 boys and 7 girls) with no urinary symptoms were assessed.
|
31432572 |
2019 |
|
Urinary Stress Incontinence
|
0.010 |
Biomarker
|
disease |
BEFREE |
At baseline, urinary levels of NGF and BDNF were similar between SUI and healthy women (NGF: 2.10 ± 0.68 vs 1.99 ± 1.05; BDNF: 1.99 ± 0.71 vs 1.81 ± 0.90), and significantly inferior to OAB wet patients (NGF: 2.10 ± 0.68 vs 2.50 ± 0.54, P < .05; BDNF: 1.99 ± 0.71 vs 2.71 ± 0.45, P < .05).
|
27697460 |
2017 |
|
Urinary Bladder, Underactive
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Urinary NGF levels were significantly higher than normal in patients with DU (9.2 ± 20.3 vs 1.85 ± 2.9 pg/ml, p = 0.037).
|
28770419 |
2017 |
|
Urinary Bladder Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Urinary nerve growth factor levels were below the detection level and did not differentiate bladder diseases from healthy controls.
|
27378135 |
2017 |
|
Unipolar Depression
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Harm avoidance involved in mediating the association between nerve growth factor (NGF) gene polymorphisms and antidepressant efficacy in patients with major depressive disorder.
|
26021968 |
2015 |
|
Unipolar Depression
|
0.020 |
Biomarker
|
disease |
BEFREE |
Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder.
|
31170316 |
2019 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To analyse the concomitant presence of NGF and its high affinity receptor TrkA in patients undergoing surgery for Crohn's disease (CD) and ulcerative colitis (UC).
|
10764711 |
2000 |
|
Tumor-Associated Vasculature
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nerve Growth Factor Facilitates the Innervation of Perivascular Nerves in Tumor-Derived Neovasculature in the Mouse Cornea.
|
27694752 |
2017 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Previous progress has indicated that nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), two NTF family members, may be involved in the process of tumor progression.
|
29391888 |
2018 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
A loss of activation of the NGF/TrkA pathway occurs during tumour progression and may contribute to loss of tumour differentiation in esophageal cancer.
|
10769644 |
2000 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The neurotrophic tyrosine kinase receptor TrkA (NTRK1) and its ligand nerve growth factor (NGF) are emerging promoters of tumor progression.
|
29802376 |
2018 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Studies have shown that several types of cancer overexpress neurotrophins such as NGF and BDNF, which might contribute to tumor progression and angiogenesis.
|
31608227 |
2019 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TrkAIII antagonizes NGF/TrkAI signaling, which is responsible for NB growth arrest and differentiation through Ras/MAPK, and its expression is promoted by hypoxia at the expense of NGF-responsive receptors, providing a mechanism for converting NGF/TrkA/Ras/MAPK antioncogenic signals to TrkAIII/IP3K/Akt/NF-kappaB tumor-promoting signals during tumor progression.
|
15488758 |
2004 |